Single versus combination intravenous anti-pseudomonal antibiotic therapy for people with cystic fibrosis
نویسندگان
چکیده
منابع مشابه
Single versus combination intravenous anti-pseudomonal antibiotic therapy for people with cystic fibrosis.
BACKGROUND Choice of antibiotic, and the use of single or combined therapy are controversial areas in the treatment of respiratory infection due to Pseudomonas aeruginosa in cystic fibrosis (CF). Advantages of combination therapy include wider range of modes of action, possible synergy and reduction of resistant organisms; advantages of monotherapy include lower cost, ease of administration and...
متن کاملSafety of intravenous tobramycin in combination with a variety of anti-pseudomonal antibiotics in children with cystic fibrosis
OBJECTIVES Previous studies have examined renal safety of once daily intravenous tobramycin in individuals with cystic fibrosis. This has been mainly in combination with ceftazidime in an adolescent or adult population. In this report, we describe our institutional experience of once daily intravenous tobramycin in combination with a variety of second anti-pseudomonal antibiotics in children wi...
متن کاملHome versus hospital intravenous antibiotic therapy for acute pulmonary exacerbations in children with cystic fibrosis.
To compare the effectiveness of home versus hospital intravenous (IV) antibiotic therapy for acute pulmonary exacerbations in children with cystic fibrosis (CF). A retrospective chart review was performed of 143 encounters for pulmonary exacerbations in 50 patients with CF. All encounters were categorized into two groups based on location of completion of antibiotic therapy: hospital group comp...
متن کاملHome versus hospital intravenous antibiotic therapy in the treatment of young adults with cystic fibrosis.
We wanted to investigate whether home intravenous antibiotic treatment of pulmonary exacerbations of cystic fibrosis is as effective as treatment in hospital. The case records of all patients attending the Leeds adult cystic fibrosis clinic were reviewed to identify those who had received home intravenous antibiotic treatment. All home treatments undertaken were included. For each home treatmen...
متن کاملA Combination Therapy for Cystic Fibrosis
The most prevalent form of cystic fibrosis arises from an amino acid deletion in the cystic fibrosis transmembrane conductance regulator, CFTR. A recently approved treatment for individuals homozygous for this mutation combines a chemical corrector, which helps CFTR fold, and a potentiator that increases CFTR channel activity.
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ژورنال
عنوان ژورنال: Cochrane Database of Systematic Reviews
سال: 2016
ISSN: 1465-1858
DOI: 10.1002/14651858.cd002007.pub4